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Associate Scientist I/II, Bioinformatics

Company: AbbVie
Location: Crystal Lake
Posted on: January 11, 2020

Job Description:

The Genomics Research Center (GRC) is a center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards our goal of developing world class genetics and genomics research, focusing on finding the right targets and helping us better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials. Within the GRC, the Department of Bioinformatics is responsible for data analysis and provides analytical insight for both internal and external data. This involves the identification and characterization of underlying genetic, epigenetic, or genomic factors that are associated with disease diagnosis, prognosis and response (efficacy and safety) to drug treatment, identification of new targets, and interpretation of the impact of genetic and genomic evidence from population-based studies. We have an exciting opportunity for a Bioinformatics Analyst based in North Chicago, IL. This role involves working closely with Senior Scientists in Bioinformatics to answer common questions as part of data analyses arising from a variety of data sources. These include RNA-seq from human trials as well as animal studies, CRISPR knockout experiments, and population scale genetic data (hundreds of thousands of samples). You will be a member of a growing team of over 20 computational scientists in Lake County, with close mentoring and opportunity to grow and develop in new areas. As part of this role, data management and manipulation of large datasets will be in your scope of your responsibilities. Position will be hired based on level of experience. Bachelor's or Master's degree in Bioinformatics, Statistics, Computer Science, Mathematics, or relevant field or a combination of relevant experience and education. Computer programming skills (e.g. familiarity with UNIX-like OS, and at least one programming language). Proficient with Linux in a scientific research environment. Well versed with genomics data, analytical tools, and concepts. Capable of executing analysis pipelines and basic interpretation of results Ability to think, analyze, and learn individually. Strong communication skills, and ability to present project work effectively. Ability to develop professional relationships with team members. Preferred Qualifications Must have knowledge and experience for genome-wide association studies (GWAS) and RNA-seq or microarray gene expression data analysis. Statistical knowledge required of genome-wide association analysis and interpretation (e.g., case-control study, logistic regression, p-value, effect size, odd ratio, type I and II errors in multiple testing, linkage disequilibrium) Experience in algorithmic implementation, statistical programming and data manipulation, using e.g. PLINK, R/Bioconductor, Python, SNPTEST, UCSC Genome Browser Familiarity with publicly available genomics resources (e.g. GTEx, TCGA, gnomAD, ClinVar, HPO, etc.) Excellent written and verbal communication skills, with demonstrated ability to stay abreast of current bioinformatics techniques and resources.

Keywords: AbbVie, Crystal Lake , Associate Scientist I/II, Bioinformatics, Other , Crystal Lake, Illinois

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