Job Description About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines
that solve serious health issues today and address the medical
challenges of tomorrow. We strive to have a remarkable impact on
people’s lives across several key therapeutic areas: immunology,
oncology, neuroscience, eye care, virology, women’s health and
gastroenterology, in addition to products and services across its
Allergan Aesthetics portfolio. For more information about AbbVie,
please visit us at www.abbvie.com . Follow @abbvie on Twitter ,
Facebook , Instagram , YouTube and LinkedIn .
The Genomics Research Center (GRC) is a center of excellence for
genetics and genomics that supports both Discovery and Development.
The GRC goal is to develop world class genetics and genomics
research focused on finding the right targets and helping AbbVie
scientists better understand not only human disease biology but
also the behavior of and response to our drugs in clinical trials
across all therapeutic areas. AbbVie has committed to obtaining a
range of Omics data on more than 1 million participants from
Genomics Medicine Ireland, FinnGen and the UKbiobank, as well as
our clinical trials. Over 300,000 data sets are already in house.
This leader will be responsible for building strategies and
solutions to “functionalize” variants that are critical to
understanding disease processes and therefore potential targets for
new therapeutics across all therapeutic areas and leading at least
three departments within the GRC. We have an exciting opportunity
for a Senior Director , based in Lake County, Illinois.The
candidate will be on the Executive Leadership Team of the GRC and
play a critical role in helping to lead and shape genomics
activities across AbbVie.
Lead a series of teams positioned to conduct validation studies,
based on results from genetic and genomic studies, that leverage
cellular (cell lines and iPSCs) models, in vitro tissue systems up
to whole animal systems to help investigators in therapeutic areas
maximize the value.
Develop strategies and solutions to rapidly “functionalize”
large numbers of variants implicated in various diseases across
Therapeutic Areas from our different population cohorts and
clinical trial cohorts.
Implement cellular assays to assess biological pathways and gene
sets that mechanistically link the gene targets to disease(s),
leveraging our extensive infrastructure, e.g. Compact SelecT
automated cell culture system, SeahorseXF and Operetta cell imaging
systems for cell biological work.
Deploy pooled and array based CRISPR technologies and libraries
for whole genome screening to variant modification.
Represent the GRC on various discovery and clinical teams
involved in a range of drug pipeline activities seeking to
understand the disease process.
Participate in the leadership of the GRC.
Collaborate with scientists across different Early Discovery
therapeutic areas to interpret and incorporate genetic findings
into new targets or for validation of existing targets
Lead groups developing new models (cellular, organoids and whole
animal) to validate targets of interest.
Level and compensation will be commensurate with experience.
MD,PhD or both with at least 10 years of industry experience in
cell biology,cellular models of human disease, and functional
Possessa strong background in applying genomic technologies to
identify genesresponsible for common complex disease and rare
Demonstratedability to design and lead genetic and genomic
studies delivering novelfindings and medically relevant gene
discoveries leveraging cell-based assays.
Demonstratedleader of high functioning teams.
Additional desired skills include:
Experiencewith multidisciplinary teams on both the basic
research and clinical questions
Deepknowledge of translating genomic data into clinically
Experiencein Immunology, Neuroscience or Oncology would be a
Experiencewith large-scale research projects involving next
generation DNA sequencingdata (e.g. whole exome and whole genome)
in conjunction with results frominformatics and wide array of
molecular biology strategies.
Experienceor strong knowledge of pharmacogenomics or
Experiencewith deploying iPSCs for drug discovery.
Strongcommunication skills in a collaborative environment
Significant Work Activities
Continuous sitting for prolonged periods (more than 2
consecutive hours in an 8 hour day)
Yes, 15 % of the Time
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse
backgrounds to develop new and innovative solutions for patients.
As an equal opportunity employer we do not discriminate on the
basis of race, color, religion, national origin, age, sex
(including pregnancy), physical or mental disability, medical
condition, genetic information gender identity or expression,
sexual orientation, marital status, protected veteran status, or
any other legally protected characteristic.
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