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Senior Scientist-Genome Biology

Company: AbbVie
Location: Crystal Lake
Posted on: September 15, 2019

Job Description:

AbbVie Inc. is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world's most complex and critical conditions. The Genomics Research Center (GRC) is a center of excellence for genetics and genomics that supports both Discovery and Development. The GRC goal is to develop world class genetics and genomics research focused on finding the right targets and helping AbbVie scientists better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials across all therapeutic areas. Genomic Research Center (GRC) has an opening for a Senior Scientist in the Genome Biology group. This position will provide opportunities to devise innovative solutions in discovery new therapeutic targets through the implementation and utilization of cutting-edge science and state-of-the-art equipment to address gene function and causal variants. Key Responsibilities Expanding genome engineering capabilities in GRC/Genome Biology Group and by collaboration throughout AbbVie Inc. Master different platforms of whole genome and specific sequence dependent targets screening using diverse cell lines and tissues. Characterize chromatin interactions and epigenetic landscape in cells and tissues of interests. Implement functional assays on the cell level. Keep accurate and current records of research and/or project related activities according to AbbVie policies. Contribute to writing of publications, presentations, and patents. Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program. Provide scientific leadership to develop creative/innovative cell-based assays to discover new targets and innovative application engineered cells to enhance internal capabilities. Level and compensation will be commensurate with experience. Basic Qualification BS, MS, PhD or M.D. in field closely related to genetic/genomic and at least 10+ (BS), 8+ (MS), or 0+ (PhD) years of experience in academia or industry. Proficiency working with the diverse primary and modified cell lines expose to different stressors. Skilled in molecular/cell techniques including cell sorting, cell transfection and transduction, western blot, qRT-PCR, gel shift, extensive experience working with lentivirus, as examples. Experience using gene editing tools (CRISPR, TALEN, or ZFN). Experience with various genomic technologies such as RNAi, NGS, RNA Seq, ChIP (chromatin immunoprecipitation), ChIP-seq, as examples. Expertise in analysis of genetic variation from next generation sequencing data and/or genome wide association studies (GWAS). Experience analyzing and interpreting family-based and rare disease genetic databases. Publication record supporting required basic qualifications preferentially as the first author in peer review journal. Preferred: Proficiency in cellular and genomic analyses including functional evaluation of coding and non- coding DNA sequences. Ph.D with 4+ years of experience in academia or industry. Excellent communication and project management skills. Proven track record of teamwork, adaptability, innovation, and integrity. Global mindset to thrive in a diverse culture and environment. Key AbbVie Competencies Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance. Learns fast, grasps the "essence" and can change the course quickly where indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Keywords: AbbVie, Crystal Lake , Senior Scientist-Genome Biology, Other , Crystal Lake, Illinois

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