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Senior Scientist I - II - III, Drug Product Development

Company: AbbVie
Location: Crystal Lake
Posted on: November 8, 2019

Job Description:

Drug Product Development is responsible for understanding the biopharmaceutical properties of candidate molecules for translation into the design and manufacture of patient centric dosing regimens. We have a challenging opportunity for a Senior Scientist based in the Biopharmaceutics and Drug Absorption group in North Chicago, IL AbbVie is seeking a highly motivated, collaborative scientist with a proven track record in characterizing the absorption behavior of small-molecule drug candidates to achieve the design of formulations that meet required in vivo performance. Key responsibilities include: Collaboration with preclinical formulation scientists to design and execute experiments that characterize the biopharmaceutical properties of small molecule candidates Collaboration with preclinical scientists to understand and model the impact of small molecule biopharmaceutical properties on oral drug absorption Provision of in vitro drug release data to formulation scientists to elucidate the impact of formulation variables and drug release on in vivo performance Interface with project teams to ensure that biopharmaceutics considerations are incorporated into the optimization of the drug-like properties of small molecule candidates. Interface to project teams to ensure biopharmaceutics considerations are incorporated into the design of preclinical and clinical formulation s Basic: Bachelor's Degree in Chemical Engineering, Pharmaceutical Sciences, Physical Pharmacy Biopharmaceutical Sciences, or Medicinal Chemistry and typically 10 years of experience OR Master's Degree in Chemical Engineering, Pharmaceutical Sciences, Physical Pharmacy Biopharmaceutical Sciences, or Medicinal Chemistry and typically 8 years of experience OR PhD in Chemical Engineering, Pharmaceutical Sciences, Physical Pharmacy Biopharmaceutical Sciences, or Medicinal Chemistry and no experience necessary. Preferred: Strong knowledge of the physiological barriers to intestinal absorption of small molecules, including various potential transport and metabolism pathways. Strong knowledge in the characterization of the biopharmaceutical properties of small molecules Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species. Experience in the development of in vitro drug release methods to model in vivo performance Excellent oral and written communication skills. Demonstrated ability to work collaboratively in a crossfunctional team setting. Key AbbVie Competencies: Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance. Learns fast, grasps the "essence" and can change the course quickly where indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Keywords: AbbVie, Crystal Lake , Senior Scientist I - II - III, Drug Product Development, Other , Crystal Lake, Illinois

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